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EDITED BY

Christopher A. Shaw and Jessica R. Morrice

University of British Columbia, Canada

This edition first published 2021

© 2021 John Wiley & Sons Ltd

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Library of Congress Cataloging‐in‐Publication Data

Names: Shaw, Christopher A. (Christopher Ariel), editor. | Morrice, Jessica R., editor.

Title: Spectrums of amyotrophic lateral sclerosis : heterogeneity, Pathogenesis and therapeutic directions / edited by Christopher A. Shaw and Jessica R. Morrice.

Description: Hoboken, NJ : Wiley-Blackwell, 2021. | Includes bibliographical references and index.

Identifiers: LCCN 2021003406 (print) | LCCN 2021003407 (ebook) | ISBN 9781119745495 (hardback) | ISBN 9781119745501 (adobe pdf) | ISBN 9781119745518 (epub)

Subjects: MESH: Amyotrophic Lateral Sclerosis–genetics | Amyotrophic Lateral Sclerosis–drug therapy | Genetic Heterogeneity | Spectrum Analysis | Models, Genetic

Classification: LCC RC406.A24 (print) | LCC RC406.A24 (ebook) | NLM WE 552 | DDC 616.8/39–dc23

LC record available at https://lccn.loc.gov/2021003406LC ebook record available at https://lccn.loc.gov/2021003407

Cover Design: Wiley

Cover Image: © Emma McEachern

This book is dedicated to people living with ALS, their families, and those who care for them.

Christen G. Chisholm, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia

Roger S. Chung, Motor Neuron Disease Research Centre, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia

Robert A. Déziel, CNS Contract Research Corp, Charlottetown, Prince Edward Island, Canada

Patrick A. Dion, Montreal Neurological Institute and Hospital, McGill University, Montréal, Québec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada

Angela Genge, Montreal Neurological Institute and Hospital, Montréal, Québec, Canada

Daphne A. Gill, CNS Contract Research Corp, Charlottetown, Prince Edward Island, Canada; Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada

Manuel Graeber, Brain Tumor Research Laboratories, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia

Cheryl Y. Gregory‐Evans, Experimental Medicine Program, University of British Columbia, Vancouver, British Columbia, Canada; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada; Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada

Denis G. Kay, Alpha Cognition Inc., Charlottetown, Prince Edward Island, Canada

Charles Krieger, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Division of Neurology, Vancouver Coastal Health, Vancouver, British Columbia, Canada

Michael Kuo, Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada

Audrey Labarre, Department of Neuroscience, University of Montréal, Montréal, Québec, Canada; Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada

Serena Lattante, Unità Operativa Complessa di Genetica Medica, Dipartimento di Scienze di Laboratorio e Infettivologico, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

Albert Lee, Motor Neuron Disease Research Centre, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia