Drug Transporters

Library of Congress Cataloging‐in‐Publication Data

Names: You, Guofeng, editor. | Morris, Marilyn E., editor.

Title: Drug transporters : molecular characterization and role in drug disposition / edited by Guofeng You, Marilyn E. Morris.

Other titles: Drug transporters (2007)| Wiley series in drug discovery and development

Description: Third edition. | Hoboken, NJ : Wiley, [2022] | Series: Wiley series in drug discovery and development | Includes bibliographical references and index.

Identifiers: LCCN 2022000523 (print) | LCCN 2022000524 (ebook) | ISBN 9781119737551 (cloth) | ISBN 9781119739869 (adobe pdf) | ISBN 9781119739876 (epub)

Subjects: MESH: Biological Transport–physiology | Membrane Transport Proteins | Pharmacokinetics

Classification: LCC QH601(print) | LCC QH601(ebook) | NLM QU 120| DDC 571.6/4–dc23/eng/20220120

LC record available at https://lccn.loc.gov/2022000523LC ebook record available at https://lccn.loc.gov/2022000524

Cover Design: Wiley

Cover Image: Courtesy of Lauren Aleksunes (Created in part with BioRender.com)

We would like to dedicate this book to our students, postdocs, and colleagues who have challenged and inspired us in our careers, and to our families William, Sarah, Jacqueline, and Kathleen Morris and Yifan and Peter Zhou who remain a continuing source of love and support in our lives.

Jeffry Adiwidjaja, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia

Lauren M. Aleksunes,Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA

Suresh V. Ambudkar,Laboratory of Cell Biology, Transport Biochemistry Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Ebehiremen N. Ayewoh,Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, USA

Agnes Basseville,Bioinformatics Unit, Institut de Cancérologie de l'Ouest, Saint Herblain, France

Susan E. Bates,Division of Hematology/Oncology, Columbia University Medical Center, New York, NY, USA

Reina Bendayan,Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

Rajinder K. Bhardwaj,Integrated Drug Development, Cetera Strategic Consulting, Parsippany, NJ, USA

Kim L. R. Brouwer,Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Dina Buitrago,Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA

Stephen M. Carl,Department Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, IN, USA; Discovery Pharmaceutics and Analytical Sciences, Bristol‐Myers Squibb Research Institute, Princeton, NJ, USA

Cindy H. Chau,Genitourinary Malignancies Branch, Molecular Pharmacology Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Eugene C. Chen,Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA, USA

Ayman El‐Kattan,DMPK, IFM Therapeutics, Boston, MA, USA

Osatohanmwen Jessica Enogieru,Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA; Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, CA, USA

Melanie A. Felmlee,Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific, Stockton, CA, USA

William D. Figg,Genitourinary Malignancies Branch, Molecular Pharmacology Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Azusa Futatsugi,Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Vadivel Ganapathy,Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, USA

Kathleen M. Giacomini,Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA

Rajgopal Govindarajan,Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA

Jeffry C. Granados,Department of Bioengineering, University of California, San Diego, CA, USA

Olafur Gudmundsson,Discovery Pharmaceutics and Analytical Sciences, Bristol‐Myers Squibb Research Institute, Princeton, NJ, USA

Matthew D. Harwood,Simcyp Division, Certara UK Ltd., Sheffield, UK

Dea Herrera‐Ruiz,Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, México

Robert S. Jones,Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA, USA

Melanie S. Joy,Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA

Yukio Kato,Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Richard B. Kim,Departments of Medicine, Physiology & Pharmacology and Oncology, The University of Western Ontario, London, Ontario, Canada

Franziska Klein,Dr. Margarete Fischer‐Bosch Institute of Clinical Pharmacology, University of Tuebingen, Stuttgart, Germany; Cluster of Excellence iFIT (EXC2180) “Image‐Guided and Functionally Instructed Tumor Therapies”, University of Tuebingen, Tuebingen, Germany

Gregory T. Knipp,Department Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, IN, USA

Megan L. Koleske,Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA

Deanna L. Kroetz,Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA

Nisha V. Kwatra,Division of Inflammation and Immune Pharmacology, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA

Yurong Lai,Drug Metabolism, Gilead Sciences Inc., Foster City, CA, USA

Xiaomin Liang,Drug Metabolism, Gilead Sciences Inc., Foster City, CA, USA

Sabrina Lusvarghi,Laboratory of Cell Biology, Transport Biochemistry Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Kazuya Maeda,Laboratory of Pharmaceutics, Kitasato University School of Pharmacy, Minato‐ku, Tokyo, Japan

Qingcheng Mao,Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA, USA

Yusuke Masuo,Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Marilyn E. Morris,Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA

Stephanie Mowery,Department Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, IN, USA; Novo Nordisk Research Center, Indianapolis. Inc., Biology Indianapolis, IN, USA