Joseph Goldberger: The Transmissibility of Pellagra: Experimental Attempts at Transmission to the Human Subject

Salient clinical features. —Weak, tongue slightly red, constipated; moderately extensive, active eruption. History of attack in 1912 and 1915.

Severity. —Rated l bjf Dr. Grimm as a moderately acute third recurrent attack.

Experimental material.— Furnished epidermal scales, urine, and feces June 25, 1916.

No. 15.

H-V.—White female, 21 years. Admitted to United States Pellagra Hospital, Spartanburg, S. C.,June 24, 1916. Hospital No. 212.

Salient clinical features. —Presents moderately extensive, acute skin manifestations; mild mental symptoms (apathetic, confused). History of a first attack in June, 1915.

Severity. —Dr. Grimm rates this as a moderately acute second attack.

Experimental material. —Furnished urine and feces June 25, 1916.

No. 16.

S-S.—White female, 30 years. Admitted to United States Pellagra Hospital, Spartanburg, S. C, June 24,1916.

Salient clinical features. —History of an attack, 1915, and of a recurrence in March, 1916, followed by improvement in April, but with retrogression during May and June. On admission felt weak, nervous, without nausea, but with burning and pain in stomach and with burning of feet. No other gastrointestinal manifestations. No eruption nor residuals of one.

Severity. —Mild second attack in posteruptive stage (or in interval) with mild suggestive symptoms.

Experimental material. —Furnished urine and feces Juno 25, 1916.

No. 17.

Q-LV.—White female, 25 years. Admitted to United States Pellagra Hospital, Spartanburg, S. C, June 24,1916. Hospital No. 216.

Salient clinical features. —Presents definite skin eruption and mild suggestive symptoms (nervousness, weakness).

Gives history of an attack in 1913 and of one in 1915.

Severity. —Rated by Dr. Grimm as a mild third recurrent attack.

Experimental material. —Furnished epidermal scales and urine June 25, 1916,

1916. Goldberger (Joseph) : Pellagra: Causation and a Method of Prevention. Journal American Medical Association, Chicago, February 12, 1916, vol. 66, pp. 471-476.

1915. Goldberger (Joseph) and Wheeler (G. A.) : Experimental Pellagra in the Human Subject. Public Health Reports, Washington, D. C, November 12, 1915.

1913. Harris (W. A.) : The Experimental Production of Pellagra in the Monkey. Journal American Medical Association, September 26, 1914, vol. 63, pp. 1093-1094.

1914. Lavinder (C. H.), Francis (Edward), etc.: Attempts to Transmit Pellagra to Monkeys. Journal American Medical Association, September 26, 1914, vol. 63, pp. 1093-1094.

1916. Vedder (E. B.) : Dietary Deficiency as the Etiological Factor in Pellagra. Arch. Int. Med., Chicago, August, 1916.

1914. Voegtlin (Carl) : Discussion of Summary of Second Progress Report of Thompson McFadden Commission. Journal American Medical Association, September 26, 1914, vol. 63, p. 1098.