Грег Иган - Teranesia

Madhusree shook her head despairingly. ‘Junkies use sonics: transdermal acoustic delivery systems that make the skin permeable to small molecules like opiates. There’s no risk of infection, because viruses are too large to get through. How do you think hepatitis C got wiped out?’

‘I knew all that,’ he lied. He applied the swab then slid the needle carefully into the crook of his elbow, but the dinghy lurched just as he was applying pressure, and the needle transected the vein. ‘Fuck.’ He steeled himself, then tried again at a different point; this time the blood spurted satisfyingly into the low-pressure sample tube. ‘How often do we have to do this?’

‘Every couple of hours at first, just to see what’s going on.’

Prabir left the hypodermic in place and flung the tube of blood across to Madhusree. A valve had shut off the flow automatically, but it was awkward trying to stop the needle slipping out. ‘Have you got some tape or something? I might as well keep this in.’

‘Good idea. There’s an anticoagulant coating on the needle, so it won’t clog up. But you knew that, of course.’ She tossed him a packet of band aids.

‘What are you looking for? In the samples?’

‘Levels of the gene, tissue types affected.’ Madhusree tinkered with one of Grant’s silver boxes until it emitted an encouraging boot-up chime.

‘Tissue types?’

She fed the blood to the machine. ‘If the gene is being incorporated into various kinds of cells in your body, occasionally one will break free and end up in your bloodstream. If I sort the cells with flow cytometry before bursting them and probing the DNA, I can track what’s happening.’

Prabir said, ‘It should only be in my testes, though, shouldn’t it? I mean, it has a promoter that will only switch it on during meiosis, so why bother incorporating anywhere else?’

The machine began whirring. Madhusree looked up and said encouragingly, ‘I hope it hasn’t even got a hold there. We’ll probably never know how it got into your bloodstream, but it certainly hasn’t come to you via another mammal, so its past experience is of limited relevance. Nothing works the first time in a new environment.’

‘You don’t believe in Furtado’s theory, then?’

She laughed and said flatly, ‘No.’

Prabir didn’t challenge her to provide her own explanation; he didn’t want to derail her, he didn’t want to erode her confidence. She’d track the gene through his body, and they’d fight it. However it worked, whatever it did.

When the sun cleared the water there was no land in sight, though Prabir could see Teranesia’s peak to their west through the binoculars. Straight ahead he saw nothing but sea. They wouldn’t reach Yamdena till midnight.

Madhusree said, ‘First results. Are you ready?’

‘Yeah.’

‘The São Paulo gene’s been incorporated into spermatogenic stem cells, complete with the usual promoter.’

Prabir nodded acceptingly. He’d been prepared for that, and however tainted it made him feel, a transplant could still rid him of the gene completely.

‘But it’s also present in dermal stem cells. With a different promoter.’

‘In my skin?’ He stared at her, more baffled than alarmed. ‘Why?’

Madhusree shook her head. ‘I don’t know.’

Prabir looked down at his arms and hands; they appeared perfectly normal. He lifted his shirt above his waist. There was a glossy patch on his abdomen, a shiny purplish-black region the size of a large coin. He touched it warily. The surface of his skin felt the same as ever, but when he applied enough pressure to sense what lay beneath, instead of the usual springiness of muscle he met resistance from an object as hard as bone.

‘It’s solid. It’s some kind of tumour.’ He was numb with revulsion. ‘Can you cut it out? Please?’

Madhusree said, ‘Stay calm.’

Prabir removed his life jacket and pulled off his shirt, almost dislodging the hypodermic in his haste; there were two more patches higher on his chest. He turned so Madhusree could see his back. ‘There are five,’ she announced. ‘About the same size.’

‘You could anaesthetise me with the tranquilliser gun,’ he implored her. ‘They’re not that deep. I won’t lose much blood.’ The gene would still be in his body, but he didn’t care. He wanted this visible, palpable sign of it removed.

‘Are they causing you any pain? Any burning sensation? They could be completely benign.’

‘ Benign ?’

Madhusree held her hands up, pleading with him for cool-headedness. ‘If there’s no pain or bleeding, they might only be replacing the normal dermis rather than invading other tissues. And if there’s no inflammation, at least they’re not provoking an autoimmune reaction.’

Prabir took several deep breaths. He’d handled a peppering with shrapnel better than this. He said, ‘There’s no pain, no inflammation.’

‘OK. I’ll synthesise growth factor blockers tailored to the receptors the cells are expressing. That should at least stabilise them.’

‘You can do that?’

‘Of course. It’s a second-year lab project: “Here’s a cultured organ with an unknown tumour. Characterise the tumour, and stop it growing.” ’ Madhusree regarded him tenderly across the narrow channel of water. ‘You’re going to be fine! We just have to be patient. We’ll get to Yamdena, we’ll get to Darwin, we’ll get to Toronto. And then we’ll fix you up for good.’

As Madhusree worked on the growth factor blockers, the hard, shiny plaques beneath his skin grew thicker and larger. New ones blossomed, on his arms and legs and buttocks. The sensation of their presence when he moved was strange, but only rarely painful, and Prabir took some comfort from their uselessness; the São Paulo gene was behaving as stupidly and randomly as a virus blundering into a brand-new host. Leprosy would have had about the same effect on his mating prospects. He’d hardly dared admit to the fear before, but as they’d left the island of the mangroves behind, he’d thought: It could have the power to do anything. It could have the power to make me rape my own sister .

It didn’t. If the fishermen had been affected in the same way as him, they’d probably been hounded for their disfigurement by a superstitious mob, and merely tried to defend themselves. What had happened with Grant had just happened; he was tired of probing it for significance.

He lay back between the fuel cans and watched the blue water around them sparkling in the morning sun.

Just before eight o’clock, Madhusree threw him a plastic tube with a clear, oily preparation, still warm from the machine; the synthesiser, on request, had welded the tube closed. When Prabir placed it in the hypodermic’s receptacle and hit the injection button, the various mating surfaces were sterilised by laser flash, then the tube was punctured at both ends and the contents driven into his vein.

He took another blood sample. Half an hour later, Madhusree had the results: the number of cells containing the gene had risen substantially, but that was hardly surprising given the visible evidence of his skin. If the blockers didn’t work there’d be no hiding his condition by the time they hit Yamdena, but he’d given Madhusree his account details, so even if he was crippled she could summon enough money from the net to compensate for any squeamishness people might have about giving him a ride.

He watched her at the bow of their twin vessel, checking their position against her notepad’s GPS to be sure that the motor was running true, scouring the horizon with the binoculars for landmarks, validating everything three different ways. He was not going to tell her: You’re carrying your parents’ killer. You’re saving a life that should not have been saved . He couldn’t pretend to untangle his own shame and cowardice at the thought of her knowing, from his understanding of the effect the revelation would have had on her, but he didn’t need to. He was not going to rob her of this feat. He was not going to corrupt it.