Robin Cook - Acceptable Risk

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With billions of dollars at stake, every scientist in America is fighting to discover the next Prozac, the latest "feel good" drug. Using bacterial mould first uncovered during the Salem witch trials, Edward Armstrong isolates a stunningly effective anti-depressant.

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“I’m glad I came out tonight,” Kim said.

“So am I,” Edward said.

Finally they sat down on a low concrete wall. To their left was a woman singing a plaintive ballad. To their right was a group of energetic Peruvian Indians playing indigenous panpipes.

“Stanton is truly a character,” Kim said.

“I didn’t know who to be more embarrassed for,” Edward said. “Me or you with the way he was carrying on.”

Kim laughed in agreement. She’d felt just as uncomfortable when Stanton was toasting Edward as when he’d toasted her.

“What I find amazing about Stanton is that he can be so manipulative and charming at the same time,” Kim said.

“It is curious what he can get away with,” Edward agreed. “I could never do it in a million years. In fact I’ve always felt I’ve been a foil for Stanton. I’ve envied him, wishing I could be half as assertive. I’ve always been socially self-conscious, even a little nerdy.”

“My feelings exactly,” Kim admitted. “I’ve always wanted to be more confident socially. But it just has never worked. I’ve been timid since I’ve been a little girl. When I’m in social situations, I never can think of the appropriate thing to say on the spur of the moment. Five minutes later I can, but then it’s always too late.”

“Two birds of a feather, just as Stanton described us,” Edward said. “The trouble is Stanton is aware of our weaknesses, and he sure knows how to make us squirm. I die a slow death every time he brings up that nonsense about my being a shoo-in for the Nobel Prize.”

“I apologize on behalf of my family,” Kim said. “At least he isn’t mean-spirited.”

“How are you related?” Edward asked.

“We’re true cousins,” Kim said. “My mother is Stanton’s father’s sister.”

“I should apologize as well,” Edward said. “I shouldn’t speak ill of Stanton. He and I were classmates in medical school. I helped him in the lab, and he helped me at parties. We made a pretty good team. We’ve been friends ever since.”

“How come you haven’t teamed up with him in one of his entrepreneurial ventures?” Kim asked.

“I’ve just never been interested,” Edward said. “I like academia, where the quest is for knowledge for knowledge’s sake. Not that I’m against applied science. It’s just not as engaging. In some respects academia and industry are at odds with each other, especially in regard to industry’s imperative of secrecy. Free communication is the life-blood of science; secrecy is its bane.”

“Stanton says he could make you a millionaire,” Kim said.

Edward laughed. “And how would that change my life? I’m already doing what I want to do: a combination of research and teaching. Injecting a million dollars into my life would just complicate things and create bias. I’m happy the way I am.”

“I tried to suggest as much to Stanton,” Kim said. “But he wouldn’t listen. He’s so headstrong.”

“But still charming and entertaining,” Edward said. “He was certainly exaggerating about me when he was giving that interminable toast. But how about you? Can your family truly be traced back to seventeenth-century America?”

“That much was true,” Kim said.

“That’s fascinating,” Edward said. “It’s also impressive. I’d be lucky to trace my family back two generations, and then it would probably be embarrassing.”

“It’s even more impressive to put oneself through school and become eminently successful in a challenging career,” Kim said. “That’s on your own initiative. I was merely born a Stewart. It took no effort on my behalf.”

“What about the Salem witchcraft story?” Edward asked. “Is that true as well?”

“It is,” Kim admitted. “But it’s not something I’m comfortable talking about.”

“I’m terribly sorry,” Edward said. His stutter reappeared. “Please forgive me. I don’t understand why it would make any difference, but I shouldn’t have brought it up.”

Kim shook her head. “Now I’m sorry for making you feel uncomfortable,” she said. “I suppose my response to the Salem witchcraft episode is silly, and to tell you the truth, I don’t even know why I feel uncomfortable about it. It’s probably because of my mother. She drummed it into me that it was something I wasn’t supposed to talk about. I know she thinks of it as a family disgrace.”

“But it was more than three hundred years ago,” Edward said.

“You’re right,” Kim said with a shrug. “It doesn’t make much sense.”

“Are you familiar with the episode?” Edward asked.

“I know the basics, I suppose,” Kim said. “Like everyone else in America.”

“Curiously enough, I know a little more than most people,” Edward said. “Harvard University Press published a book on the subject which was written by two gifted historians. It’s called Salem Possessed. One of my graduate students insisted I read it since it won some kind of history award. So I read it, and I was intrigued. Why don’t I loan it to you?”

“That would be nice,” Kim said just to be polite.

“I’m serious,” Edward said. “You’ll like it, and maybe it will change the way you think about the affair. The social/political/religious aspects are truly fascinating. I learned a lot more than I expected. For instance, did you know that within a few years of the trials some of the jurors and even some of the judges publicly recanted and asked for pardon because they realized innocent people had been executed?”

“Really,” Kim said, still trying to be polite.

“But the fact that innocent people got hanged wasn’t what really grabbed me,” Edward said. “You know how one book leads to another. Well, I read another book called Poisons of the Past that had the most interesting theory, especially for a neuroscientist like myself. It suggested that at least some of the young women of Salem who were suffering strange ‘fits’ and who were responsible for accusing people of witchcraft were actually poisoned. The suggested culprit was ergot, which comes from a mold called Claviceps purpurea. Claviceps is a fungus that tends to grow on grain, particularly rye.”

Despite Kim’s conditioned disinterest in the subject, Edward had caught her attention. “Poisoned by ergot?” she questioned. “What would that do?”

“Ooo-wee!” Edward rolled his eyes. “Remember that Beatles song, ‘Lucy in the Sky with Diamonds’? Well, it would have been something like that because ergot contains lysergic acid amide, which is the prime ingredient of LSD.”

“You mean they would have experienced hallucinations and delusions?” Kim asked.

“That’s the idea,” Edward said. “Ergotism either causes a gangrenous reaction, which can be rapidly fatal, or a convulsive, hallucinogenic reaction. In Salem it would have been the convulsive, hallucinogenic one, tending more on the hallucinogenic side.”

“What an interesting theory,” Kim said. “It might even interest my mother. Maybe she’d feel differently about our ancestor if she knew of such an explanation. It would be hard to blame the individual under those circumstances.”

“That was my thought,” Edward said. “But at the same time it can’t be the whole story. Ergot might have been the tinder that ignited the fire, but once it started it turned into a firestorm on its own accord. From the reading I’ve done I think people exploited the situation for economic and social reasons, although not necessarily on a conscious level.”

“You’ve certainly piqued my curiosity,” Kim said. “Now I feel embarrassed I’ve never been curious enough to read anything about the Salem witch trials other than the little I did in high school. I should be particularly ashamed since my executed ancestor’s property is still in the family’s possession. In fact, due to a minor feud between my father and my late grandfather, my brother and I inherited it just this year.”

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