Robin Cook - Critical

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Critical: краткое содержание, описание и аннотация

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Angela Dawson, M.D., appears to have it all: at the age of thirty-seven, she owns a fabulous New York City apartment, a stunning seaside house on Nantucket, and enjoys the perks of her prosperous lifestyle. But her climb to the top was rough, marked by a troubled childhood, a failed marriage, and the devastating blow of bankruptcy as a primary-care internist. Painfully aware of the role of economics in modern life, particularly in the health-care field, Angela returned to school to earn an MBA. Armed with a shiny new degree and blessed with determination, intelligence, and impeccable timing, Angela founded a start-up company, Angels Healthcare, then took it public. With her controlling interest in three busy specialty hospitals in New York City and plans for others in Miami and Los Angeles, Angela's future looked very bright.
Then a surge of drug-resistant staph infections in all three hospitals devastates Angela's carefully constructed world. Not only do the infections result in patient deaths, but the fatalities also cause stock prices to tumble, leaving market analysts wondering if Angela will be able to hold her empire together.
New York City medical examiners Laurie Montgomery and Jack Stapleton are naturally intrigued by the uptick in staph-related post-procedure deaths. Aside from their own professional curiosity, there's a personal stake as well: Laurie and Jack are newly married, and Jack is facing surgery to repair a torn ligament at Angels Orthopedic Hospital. Despite Jack's protests, Laurie can't help investigating-opening a Pandora's box of corporate intrigue that threatens not just her livelihood, but her life with Jack as well.

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"Unfortunately, the autopsy is not going to provide us with an answer to that question," Jack said.

Laurie excused herself and exited via the washroom to ditch her gloves and Tyvek disposable suit. Her face mask she wiped clean with alcohol and left it in her locker. Intent on not keeping Marvin waiting, she dashed upstairs.

Back in her office, Laurie dialed Dr. Silvia Salerno at the CDC. As the call went through, she wedged the phone between her head and shoulder to free her hands. Shuffling through the case files on her desk, she located Chet's case, Julia Francova. She opened it up with the hopes of being able to add the subtyping of the patient's MRSA.

When the phone wasn't answered immediately, Laurie looked at the time. It was now going on nine, and she was certain the CDC had to be open for business. "Come on, come on!" Laurie urged. "Answer the damn phone."

Just when she thought about checking to see if the CDC had a paging system, the line was picked up. It was Silvia, and she was mildly out of breath. She immediately apologized, saying she had been in a neighboring office.

"I hope I'm not bothering you," Laurie said. "I know you said you'd be calling me, but the sooner I have some information, the better."

"Don't be silly," Silvia said. "You certainly aren't bothering me, and I was planning on calling this morning. I did check on those two MRSA cases of Dr. Mehta's. They are the same organism, and I can say that with definite certainty. Because we are adding these strains to the national library of MRSA, we go out of our way to characterize them, and we do this with multiple genetic methods, such as high-throughput amplified fragment-length polymorphism analysis. I could send you a list of the other methods we use."

"Thank you, but I don't believe that will be necessary," Laurie said. She had no idea what Silvia was talking about. "But I do have another case, which had been sent to you people a number of weeks ago for typing. Specifically, it was sent to a Dr. Percy."

"Dr. Percy is a colleague. What was the referring doctor's name?"

"Dr. Chet McGovern. He's a colleague of mine here at the OCME."

"What was the patient's name?"

Laurie spelled out the name to avoid any confusion.

"Hang on for a minute."

Laurie could hear the familiar sound of Silvia's keyboard, making her wonder how anything got done before digital computers.

"Yes, here it is," Silvia said. "Interesting! It's also CA-MRSA, USA four hundred, MWtwo, SCCmecIV, PVL, exactly like the two previous cases. Is it from the same institution?"

"It's from one of the same institutions," Laurie said. "Remember, the first two were from two separate hospitals."

"Yes, I remember. Concerning the two cases at the same institution, are they close to each other in time, maybe even the same date?"

Laurie turned to her unfinished matrix, but she did have the data from Mehta's case from the Angels Cosmetic Surgery and Eye Hospital. The patient's name was Diane Lucente, and like Ramona, she'd had liposuction. Laurie checked the date of Diane's death and Chet's case. "No," Laurie said. "They occurred almost three weeks apart."

"How odd," Silvia said. "I guess you know how genetically versatile staphylococcus is."

"I'm on a rather steep learning curve," Laurie admitted. "But I was informed of that yesterday."

"I find that the exact subtype being separated by institution and time quite amazing. All three must have been in contact with the same carrier."

"Did you have this specific subtype in your collection before Dr. Mehta sent you the isolate?"

"Yes, we did. As I told you last time, it is one of the most virulent subtypes we've seen for all sorts of test animals as well as humans."

"Do you send out cultures of these organisms?"

"We do. We support any number of researchers willing to work with these organisms."

"Have you ever sent this particular organism to New York City?

"I don't know offhand, but I can find out."

"I'd appreciate it," Laurie said. The nagging concern of the bacteria being spread purposefully resurfaced in Laurie's brain, yet the old arguments against such an idea resurfaced as well, each essentially canceling the other.

"I have asked around the center if anyone was aware of the cluster of MRSA cases you are investigating, but no had heard about it."

"Is that odd or not?" Laurie asked.

"No. It's up to the individual institutions if they want to contact us for assistance. There's no mandatory reporting to us, but there probably is to the state or city authorities."

"Did you get the other isolates I had our microbiology department overnight to you?"

"Yes, I did. They are in the works. I shall have some results in two to three days – four, tops."

Laurie thanked the woman for her help and rang off. For a moment, she sat at her desk and went over the conversation. She had to admit that the call had deepened the mystery, not solved it.

Suddenly remembering the time, she leaped up from her desk and dashed for the elevator. She was afraid she had once again kept Marvin waiting despite her promise not to do so.

CARLO FOLLOWED BRENNAN out of the electronics store on Lexington Avenue in Manhattan. Brennan had purchased a GPS tracking device from a company that specialized in marine as well as terrestrial applications. Once outside, they found that it had started to sprinkle, so they ran for the black GMC Denali.

"I'm glad to see it started to rain," Carlo said, as he revved the engine before pulling out into the traffic.

"How come?" Brennan asked, absorbed in slitting the cellophane wrapping of the box containing the tracking device. He loved electronic contrivances and had had a ball picking out the item. He'd spent such a long time discussing with the salesman the pluses and minuses of the array of tracking devices the store carried that Carlo had become totally bored.

"Because there'll be less chance of people hanging around the marina. I don't want anyone seeing us hiding the thing on the boat. You know what I'm saying?"

Brennan didn't answer. Instead, he was easing the tracking device out of the box's foam interior.

"Hey!" Carlo demanded. He didn't like to be ignored. "Are you listening to me?"

"Sort of," Brennan admitted. He looked into the depths of the molded foam packing material.

"I'm talking about the rain and the marina. I asked you if you agreed it was to our advantage it was raining."

Brennan at last found what he was looking for. It was a packet containing an operating directions booklet but, more important, an online registration code.

"Well?" Carlo questioned with irritation.

Brennan next used his penknife on the packaging for the device itself, but before he could free it from its cellophane mummification, his head snapped forward from an openhanded blow from Carlo.

"What the hell!" Brennan yelled. He turned and glared at Carlo. "What did you hit me for?" he growled.

"I was talking to you," Carlo yelled back. "You were ignoring me. I don't like to be ignored. It pisses me off."

Brennan stared at Carlo. He was in a momentary rage. Luckily, he controlled himself, since Carlo was behind the wheel and they were hurtling down Lexington Avenue in a clot of traffic. Carlo might have been bigger and older, but he sure as hell wasn't wiser. In fact, he was somewhat of a lunkhead, and it was that realization that enabled Brennan to calm down a degree.

"Don't hit me ever again," Brennan voiced slowly, emphasizing each syllable.

"Then don't ignore me when I'm talking to you," Carlo snapped back.

Brennan rolled his eyes, shook his head, and went back to the operating instructions. He was pretty sure how the tracking device worked, but he wanted to read up on registering it for the real-time online services.

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